The Microsaic 3500 MiD is the world’s smallest fully integrated MS system. The 3500 MiD is the size of a standard desktop computer and with very few additional infrastructure requirements it is smaller, lighter, more energy efficient and cheaper to run than conventional MS systems.
The 3500 MiD is designed to readily integrate with existing HPLC equipment with no extra footprint extending the capability of your HPLC system with significant cost savings compared to a conventional MS system.
Historically, MS has only been used for off-line analysis but the 3500 MiD is so compact it can be used for on-line reaction monitoring in a fume-hood. Monitoring batch reactions in real time provides the chemist with vital reaction data which can be acted upon to maximise yield and/or minimize impurities. The 3500 MiD is also ideal for flow chemistry systems where MS data can be used for faster reaction optimisation.
The system is portable with modular plug and play components for maximum application flexibility.
SMALLEST FOOTPRINT IN THE MARKET
Far smaller than conventional mass spectrometers, with fewer infrastructure requirements (e.g. sound- proofing, floor pump, UPS, gas generator) the Microsaic 3500 MiD is a versatile, portable solution designed for bench chemists.
STACKABLE, ONE BOX SOLUTION
Designed to integrate with existing equipment with no extra footprint.
CHIP-BASED MASS SPECTROMETRY
The 3500 MiD is a fully integrated MS system. The core technologies are chip-scale versions of traditional mass spec components which can be interchanged rapidly by the user. This modular approach allows users to maintain the system without the need for expensive service contracts and time-consuming call-outs.
spraychip®
Microspray ionisation source
vac-chip™
Micro-engineered vacuum interface
ionchip®
Chip-based quadrupole mass analyzer
CHANGE THE CHIP AS YOUR NEEDS CHANGE!
‘Plug and play’ chips make the 3500 MiD configurable, flexible and future proof.
MASSCAPE™ SOFTWARE
The 3500 MiD runs Masscape; an intuitive, open-access software for method development and LC-MS.
DATA ANALYSIS.
Masscape may be used off-line as a data analysis solution. Masscape files are in a variety of formats including NetCDF, compatible with software from major LC companies.
SAVE MONEY
10% of the running costs of conventional MS systems. Big savings on costly infrastructure such as gas generators, air-con and UPS.
MINIMAL DOWNTIME
‘Plug and play’ components allow users to maintain the system. Zero call outs.
NETWORK READY
Remote control via LAN connection removes the need for a monitor or keyboard, further minimizing footprint: ideal for fume-hood deployment.
PHYSICAL REQUIREMENTS |
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Dimensions |
60 cm * 35 cm * 18.5 cm (L) * (W) * (H) |
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Weight |
27 kg |
HARDWARE |
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Ion Source |
spraychip® |
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Ionization Modes |
Positive and negative ESI |
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Sample Inlet |
Compatible with standard LC capillarys and unions e.g. 1/16 OD tubing |
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Direct Flow Rate |
0.2µL/min - 1µL/min |
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Split Flow Rate |
1µL/min – 1.8 ml/min |
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Mass Analyzer |
ionchip® quadrupole mass spectrometer |
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Mass Range |
80-800 m/z with ionchip®150 |
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Mass Accuracy |
±0.3 m/z |
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Mass Resolution |
0.7 FWHM |
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Sensitivity |
10pg with a S/N of 10:1 rms in SIM mode using a 1µL injection of Reserpine at 150µL/min |
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Spectrum Display |
Continuum (profile) and Centroid (stick) |
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Vacuum Interface |
vac-chip™ microengineered API |
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Detector |
Electron multiplier |
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Dynamic Range |
3 orders of magnitude |
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Scan Modes |
Full scan or 8 m/z channels (SIM) |
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Scan Rate |
Up to 3,600 pts/s |
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Pumping System |
Integrated maintenance-free pumps. |
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Computer |
Integrated on-board computer |
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Operating System |
Linux Open Source |
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Connectivity |
Ethernet, 3 x USB |
ENVIRONMENTAL REQUIREMENTS |
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Operating |
10-35 °C with 40%~80% relative humidity noncondensing. |
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Storage |
-20-70 °C with 0%~90% relative humidity noncondensing |
REGULATORY COMPLIANCE |
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Safety |
IEC 61010-1: 2001 |
MASSCAPE™ SOFTWARE |
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The Masscape™ software application gives you full control of the data acquisition and analysis of your chemical samples. |
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Data Capture |
Mass spectra (profile and centroid) selected ion monitoring modes (SIM) |
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Data Analysis |
Peak integration |
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Chromatogram |
Retention time, peak height and area (integrated chromatogram) |
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Mass Spectrum |
m/z and intensity profile or centroid |
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Data Input |
Real-time analog input of UV trace and display in Masscape |
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Data Output |
Real-time analog output of TIC or SIM trace |
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Data Export |
NetCDF, Excel, CSV |
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Configuration |
May be controlled remotely over LAN. External trigger allowing automatic analysis of samples via a method table. |
UTILITY REQUIREMENTS |
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Power |
200 W (operating) 300 W (peak) |
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Nitrogen Gas |
Pressure 1- 6 bar (29 – 87 psi) |
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Pump Exhaust |
Exhaust connects to 2 * 8 mm OD push fit bulkhead connections |
WHAT SOLVENTS IS THE 3500 MID COMPATIBLE WITH?
Normal HPLC solvents are compatible.
THE FLOW RATE OF MY SYSTEM IS 1ML/MIN, CAN I USE IT WITH THE 3500 MID?
Yes, the 3500 MiD has a built in split which can take a range of flow rates up to 2 ml/min
HOW OFTEN DO YOU HAVE TO CHANGE THE CHIPS?
The 3500 MiD is modular so chips can be exchanged during routine maintenance to minimize downtime. We recommend having at least 2 spray chips for this reason. The chips can be cleaned and re-used
What infrastructure do I need?
The 3500 MiD will work with a N2 bottle. A 50L bottle will last 3 days with continuous use. Fumehood N2 supply will also work, as would a N2 generator.
Microsaic brochure
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