• Easy and fast isolation of rosmarinic acid from lemon balm with mass-directed purification

    Rosmarinic acid is a natural product widely spread over different plant families. Preparative reversed-phase chromatography was used for the mass-directed purification of rosmarinic acid from a lemon balm extract.

    Download now
  • Monitor and control your upstream bioprocessing using a deployable MS

    The new demands of bioprocessing, used to make biologics, means that there is a need for analytical instruments, such as mass spectrometers, to provide real­time information (on-line and at-line) at the point-of-need. We show how our deployable, and compact mass spectrometer sam­pling the media from a bioreactor in real-time could provide important process monitoring, and critical quality attributes of the product.

    Download now
  • Rapid Analysis of Upstream Bioprocesses Using a Point-of-Need Mass Spectrometer

    Integrated real-time MS, decentralized and at the point-of-need, could provide important process information quickly and at reduced cost. Here, the feasibility of using a deployable and compact mass spectrometer for the direct analysis of upstream cell cultures is investi­gated.

    Download now
  • Sensitive Detection of Peptides in Cytochrome C Digest Using Nano LC with Micro Pillar Array Columns (µPACTM) and Microsaic 4500 MiD® Mass Spectrometer

    Liquid Chromatography coupled with mass spectrometry is a powerful analytical tool for detection and identification of chemicals in complex mixtures. The compact nature of the Microsaic 4500 MiD® MS system and the combination of low flow rate requirements and high separation resolution that PharmaFluidics µPAC™ LC columns can offer have made this combination a perfect fit for performing targeted proteomics studies as shown in this application note.

    Download now
  • Deployable mass detection integrated into your process can enhance productivity and profitability

    Microsaic Systems‘ application portfolio ranges from traditional LC-MS analysis to previously unserved markets that will benefit from deployable mass detection at the point-of-need. In this application note the versatility of Microsaic Systems’ application range is detailed along with the benefits of enhanced process productivity and profitability by integrating simple-to-use mass detection.

    Download now
  • Rapid detection of counterfeit and adulterated alcoholic drinks by deployable and direct ESI-MS

    Using at-line direct injection MS analysis, we have demonstrated the ability to distinguish not only a difference in brands of whisky from the same distillery, but a detectable difference in different batches of the same blend. Furthermore, a test to detect the presence of denaturants or additives in whisky has been devised.

    Download now
  • Direct TLC-MS analysis using the 4000 MiD

    TLC-MS system provides an easy way to identify and elucidate unknown substances in research, forensic and environmental fields. Integration of the TLC-MS interface with the miniaturised, deployable, single quadrupole 4000MiD® mass detector provides a completely standalone and easy to use solution for TLC spot identification.

    Download now
  • At-line extraction MS analysis of caffeine in Redbull

    We report a rapid and low cost screening of caffeine in RedBull by using a hand-held automated extraction platform coupled to the 4000 MiD® mass detector.

    Download now
  • Purification of peptides and small molecules by Prep-LCMS

    Preparative liquid chromatography (Prep-LC) has become a major tool in the production of specialty chemicals. Prep-LC coupled with mass spectrometry (MS) is a well-established method for purifying target compounds. This technique allows collecting fractions with high purity and excellent recovery for target molecules by combining ultra violet (UV) and mass-based detection.

    Download now
  • Multivariate analysis of a SNAr by on-line reaction monitoring using miniaturized MS

    Investigation of the optimization of the nucleophilic aromatic substitution of 2,4-difluoro-nitrobenzene with morpholine over a wide variety of stochiometric ratios, residence times and temperatures to demonstrate all the benefits of using on-line flow reaction monitoring.

    Download now
  • HPLC-MS applications of the Microsaic 4000 MiD®

    Here we report the HPLC-MS analysis of pesticides, peptides, carbohydrates and ibuprofen to demonstrate the excellent versatility and simplicity of the Microsaic 4000 MiD® in several areas of application, such as environmental monitoring, food safety, forensics and pharmaceuticals.

    Download now
  • Bromination of a pyrrolo-pyrimidine by real-time flow reaction monitoring using MS analysis

    Report on the collaboration with Durham University using the 4000 MiD® mass spectrometer to demonstrate the benefits of on-line flow reaction monitoring of the bromination of ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate.

    Download now
  • Batch monitoring of deprotection chemistry

    Here we monitor and compare two Boc-deprotection reactions using Microsaic Systems unique mass detection and sampling platform, consisting of the MiDasTM, 4000 MiD® and stand-alone on-board Masscape® software.

    Download now
  • On-line MS using the 4000 MiD reported by Astra-Zeneca at BMSS 2013

    Report on the use of the 4000 MiD® mass spectrometer for on-line monitoring of continuous flow chemical synthesis – the Hofmann Rearrangement reaction.

    Download now
  • On-line flow reaction monitoring of Wittig reaction using deployable mass detection

    Syrris and Microsaic Systems, both R&D 100 award winning companies have set up a Flow reactor-MS system to demonstrate the benefits of using on-line flow reaction monitoring. This presents a revolutionary tool for organic chemistry synthesis.

    Download now
  • On-line batch reaction monitoring of the catalytic conversion of ethanol to an advanced biofuel

    Report on the collaboration with Bristol University using the 4000 MiD® mass spectrometer to demonstrate the benefits of on-line reaction monitoring for reactions in batch mode of the catalytic conversion of ethanol to an advanced biofuel.

    Download now