The 4500 MiD® combines the vacuum system, electronics and computer inside one box. With no floor pump ever needed, it can be installed where no other mass spectrometer can be easily deployed, all while retaining the performance of a conventional mass spectrometer system. The addition of the Microsaic MiDas™ compact interface sampling module means the 4500 MiD® can be easily deployed in a large variety of on-line, at-line and off-line applications.
Featuring Microsaic’s three main patented chip-based technologies, the ionchip®, spraychip® and vac-chip™, the 4500 MiD® is reliable, robust, and user-friendly, with increased mass range, a completely tool-less front-end for enhanced control, an intuitive and robust user interface, and improved electronics. A change in front-end alignment has also strengthened system uptime while reducing the deposition of contaminants downstream.
Increasing the mass range to 1400 m/z opens up a new range of applications, including peptide analysis using Nano LC-MS, which is ideal for the 4500 MiD®’s extremely efficient ESI source, and its strong propensity towards multiple charging.
Easy to operate and maintain, the Microsaic 4500 MiD® also offers reduced solvent, nitrogen and power consumption to lower operating costs and provide a greener solution for mass detection.
Dimensions
55 x 35 x 25 cm (22 x 14 x 10 in.) (including PC, pump and exhaust)
Weight
32 kg (including PC, pump and exhaust)
Ion Source
spraychip® - electrospray ionization source
Ionization Modes
Positive and negative ESI
Sample Inlet
Compatible with standard capillaries and unions e.g., 1/32” tubing
Flow Rate Range
0.3-2000 µL/min
Mass Analyzer
ionchip® - quadrupole mass filter
Mass Range
50-1400 m/z
Mass Accuracy
± 0.3 m/z in full scan*
Mass Resolution
0.7 m/z ±FWHM*
Sensitivity
10pg of reserpine yields a peak in SIM mode with a S/N ratio of 10:1 (RMS)
Interface
vac-chip™ - off axis microengineered atmospheric pressure interface
Detector
Electron multiplier
Dynamic Range
3-4 orders of magnitude
Scan Modes
Full scan, SIM (8m/z channels), simultaneous scan/SIM, and timed SIM
Scan Rate
m/z 1,500/s (7,500 pts/s)
Pumping System
Integrated oil-free pumps (no floor pump needed)
Software Control
Masscape®
Clarity, PrepCon, Remote Operations Protocol
Connections
Ethernet, 5 x USB
2 x digital in (e.g., LC trigger input), 2 x digital out
4 x in (e.g.; UV Trace), 4 x out (e.g., triggering external device)
1 x RS232 (e.g., syringe pump control)
*in a temperature controlled environment, 20±3˚C
Power Requirements
Power: 250W (operating), 300 W (peak)
Line voltage: 100-240 V AC±10%
Line frequency: 50/60 Hz
Nitrogen Gas
Pressure 2-6 bar (29-87 psi)
Purity (≥99,5%)
6mm OD push fit connection
Pump Exhaust
Exhaust connects to an 8 mm OD push fit
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